If two people with sickle cell disease have children, it stands to reason that all their children will also have the disease. Otherwise, it is not as straightforward.
1. If two people with sickle cell trait have children …
… with each pregnancy, there is a 25 percent chance that the child will inherit two normal genes, a 25 percent chance the child will have sickle cell disease and a 50 percent chance the child will have the trait.
2. If a person with the trait has children with a person
who has sickle cell disease …
… with each pregnancy, there is a 50 percent chance the child will have the trait and a 50 percent chance the child will have sickle cell disease.
